and: Professor of Neurology, College of Physicians and Surgeons Professor of School of Basic Medical Sciences, Beijing University Director, Center for Infection and Immunity Director, Northeast Biodefense Center
W. Ian Lipkin, MD, is internationally recognized as an authority on the use of molecular methods for pathogen discovery. Dr. Lipkin has over 30 years of experience in diagnostics, microbial discovery and outbreak response, has mentored and trained more than 30 students and post-doctoral fellows and leads a team of over 65 investigators, post-doctoral fellows and research and support staff at MSPH. In the 1980s, Dr. Lipkin identified AIDS-associated immunological abnormalities and inflammatory neuropathy, which he showed could be treated with plasmapheresis, and demonstrated that early life exposure to viral infections affects neurotransmitter function. He was the first to use purely molecular methods to identify infectious agents, implicated West Nile virus as the cause of the encephalitis epidemic in New York in 1999, assisted the WHO and the Peoples Republic of China during the 2003 SARS outbreak, developed MassTag PCR and Greenechip technology and pioneered the use of high throughput sequencing in pathogen discovery. He and his team have discovered or characterized more than 500 infectious agents including Borna disease virus, West Nile virus, LuJo virus, human rhinovrirus C, piscine reovirus and canine hepacivirus. Dr. Lipkin has been featured by the New York Times, the Los Angeles Times, Discover Magazine, Nature Medicine, the History Channel, National Geographic, National Public Radio, Wired, and the Huffington Post.
Photo courtesy: Columbia Technology Ventures: http://www.techventures.columbia.edu/
Dr. Lipkin is scientific director of the Northeast Biodefense Center, a Regional Center of Excellence in Biodefense and Emerging Infectious Diseases comprising all academic, research, and public health institutions in New York, New Jersey, Connecticut, Puerto Rico, and the Virgin Islands.
Dr. Lipkin is principal investigator of a prospective birth cohort of 100,000 women, their children and partners focused on determining the epidemiology, natural trajectory of disease, and pathogenesis of autism spectrum disorders.
World Health Organization Collaborating Centre for Diagnostics in Zoonotic and Emerging Infectious Diseases
Lipkin WI, Travis GH, Carbone KM, Wilson MC Isolation and characterization of Borna disease agent cDNA clones Proc. Natl. Acad. Sci. 87 4184-4188 1990
Schneider PA, Schneemann A, Lipkin WI RNA splicing in Borna disease virus, a non-segmented negative-strand RNA virus J. Virol. 68 5007-5012 1994
Hornig M, Weissenböck H, Horscroft N, Lipkin WI An infection-based model of neurodevelopmental damage Proc. Natl. Acad. Sci. 96 12102-12107 1999
Briese T, Jia X-J, Huang C, Grady LJ, Lipkin WI Identification of a Kunjin/West Nile-like flavivirus in brains of New York encephalitis patients Lancet 354 1261-1262 1999
Jia X-Y, Briese T, Jordan I, Rambaut A, Chi HC, Mackenzie JS, Hall RA, Scherret J, Lipkin WI Genetic analysis of the West Nile New York 1999 encephalitis virus Lancet 354 1971-1972 1999
Hoffman KL, Hornig M, Yaddanapudi K, Jabado O, Lipkin WI A murine model for neuropsychiatric disorders associated with group A β-hemolytic streptococcal infection J Neurosci 24 1780-1791 2004
Briese T, Palacios G, Kokoris M, Jabado O, Liu Z, Renwick N, Kapoor V, Casas I, Pozo F, Limberger R, Perez-Brena P, Ju J, Lipkin Diagnostic system for rapid and sensitive differential detection of pathogens Emerg Infect Dis 11 310-313 2005
Lamson D, Renwick N, Kapoor V, Liu Z, Palacios G, Ju J, Dean A, St. George K, Briese T, Lipkin WI MassTag polymerase-chain-reaction detection of respiratory pathogens, including a new rhinovirus genotype, causing influenza-like illness in New York State, 2004-2005 J Infectious Dis 15 1398 2006
Yaddanapudi K, Palacios G, Towner JS, Nichol ST, Sariol C, Lipkin WI Implication of a retrovirus-like glycoprotein peptide in the immunopathogenesis of Ebola and Marburg viruses FASEB 20 2519 2006
Palacios G, Quan P-L, Jabado OJ, Conlaan S, Hirschberg DL, Liu Y, Zhai J, Renwick N, Hui J, Hegyi H, Grolla A, Strong JE, Towner JS, Geisbert TW, Jahrling PB, Büchen-Osmond C, Ellerbrok H, Sanchez-Sec Panmicrobial oligonucleotide array for diagnosis of infectious diseases. Emerg Infect Dis In Press 2007