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W. Ian Lipkin

Director, Center for Infection & Immunity
John Snow Professor of Epidemiology

and:
Professor of Neurology, College of Physicians and Surgeons
Professor of Pathology, College of Physicians and Surgeons
Professor of School of Basic Medical Sciences, Beijing University
Director, Northeast Biodefense Center
Biography:
W. Ian Lipkin, MD, is internationally recognized as an authority on the use of molecular methods for pathogen discovery. Dr. Lipkin has over 30 years of experience in diagnostics, microbial discovery and outbreak response, has mentored and trained more than 30 students and post-doctoral fellows and leads a team of over 65 investigators, post-doctoral fellows and research and support staff at MSPH. In the 1980s, Dr. Lipkin identified AIDS-associated immunological abnormalities and inflammatory neuropathy, which he showed could be treated with plasmapheresis, and demonstrated that early life exposure to viral infections affects neurotransmitter function. He was the first to use purely molecular methods to identify infectious agents, implicated West Nile virus as the cause of the encephalitis epidemic in New York in 1999, assisted the WHO and the Peoples Republic of China during the 2003 SARS outbreak, developed MassTag PCR and Greenechip technology and pioneered the use of high throughput sequencing in pathogen discovery. He and his team have discovered or characterized more than 500 infectious agents including Borna disease virus, West Nile virus, LuJo virus, human rhinovrirus C, piscine reovirus and canine hepacivirus. Dr. Lipkin has been featured by the New York Times, the Los Angeles Times, Discover Magazine, Nature Medicine, the History Channel, National Geographic, National Public Radio, Wired, and the Huffington Post.

Photo courtesy: Columbia Technology Ventures: http://www.techventures.columbia.edu/
Education & Training:

MD, Rush University, 1978

BA, Sarah Lawrence College, 1974

Affiliation(s):

Additional Affiliations:

  • Director, Northeast Biodefense Center
  • Dalldorf Affiliated Research Physician, Wadsworth Center, New York State Department of Health
  • Principal Investigator, Autism Birth Cohort
  • NIH Blue Ribbon Panel for the Risk Assessment of the National Emerging Infectious Disease Laboratory at Boston University Medical Center
  • NIAID Blue Ribbon Panel on Genomics Research
  • Co-chair, National Biosurveillance Advisory Subcommittee
Honors and Awards:
    • Fellow, New York Academy of Sciences
    • Pew Scholar, 1991
    • Foundation Lecturer, American Society of Microbiology, 2001-2003
    • Fellow, American Association for the Advancement of Science
    • Member, Association of American Physicians

    Selected Editorial Boards

    • mBio
Selected
New York City
Activities:
    NIH (NIAID) Northeast Biodefense Center
    Project URL: http://www.nbc.columbia.edu
    Dr. Lipkin is scientific director of the Northeast Biodefense Center, a Regional Center of Excellence in Biodefense and Emerging Infectious Diseases comprising all academic, research, and public health institutions in New York, New Jersey, Connecticut, Puerto Rico, and the Virgin Islands.

Selected
Global
Activities:
    Gene: Environment Interactions in an Autism Birth Cohort Project URL: http://www.abc.columbia.edu

    Dr. Lipkin is principal investigator of a prospective birth cohort of 100,000 women, their children and partners focused on determining the epidemiology, natural trajectory of disease, and pathogenesis of autism spectrum disorders.

    Countries: Norway

    World Health Organization Collaborating Centre for Diagnostics in Zoonotic and Emerging Infectious Diseases


    Countries: World

Selected Publications:
    Hornig M, Weissenb?ck H, Horscroft N, Lipkin WI "An infection-based model of neurodevelopmental damage" Proc. Natl. Acad. Sci. 96 12102-12107 1999

    Jia X-Y, Briese T, Jordan I, Rambaut A, Chi HC, Mackenzie JS, Hall RA, Scherret J, Lipkin WI  "Genetic analysis of the West Nile New York 1999 encephalitis virus" Lancet 354 1971-1972  1999

    Hoffman KL, Hornig M, Yaddanapudi K, Jabado O, Lipkin WI  "A murine model for neuropsychiatric disorders associated with group A β-hemolytic streptococcal infection" J Neurosci 24 1780-1791 2004

    Lamson D, Renwick N, Kapoor V, Liu Z, Palacios G, Ju J, Dean A, St. George K, Briese T, Lipkin WI  "MassTag polymerase-chain-reaction detection of respiratory pathogens, including a new rhinovirus genotype, causing influenza-like illness in New York State, 2004-2005" J Infectious Dis 15 1398 2006

    Yaddanapudi K, Palacios G, Towner JS, Nichol ST, Sariol C, Lipkin WI  "Implication of a retrovirus-like glycoprotein peptide in the immunopathogenesis of Ebola and Marburg viruses" FASEB 20 2519 2006

    Briese T, de la Torre JC, Lewis A, Ludwig H, Lipkin WI "Borna disease virus, a negative-strand RNA virus, transcribes in the nucleus of infected cells." PNAS USA 89 11486 1992

    ? Cox-Foster DL, Conlan S, Holmes EC, Palacios G, Evans JD, Moran NA, Quan P-L, Briese T, Hornig M, Geiser DM, Martinson V, vanEngelsdorp D, Kalkstein AL, Drysdale A, Hui J, Zhai J, Cui L, Hutchison SK, Simons JF, Egholm M, Pettis JS, Lipkin WI  "A metagenomic survey of microbes in honey bee colony collapse disorder" Science 318 283 2007

    ? Palacios G, Druce J, Du L, Tran T, Birch C, Briese T, Conlan S, Quan P-L, Hui J, Marshall J, Simons JF, Egholm M, Paddock CD, Shieh W-J, Zaki S, Catton M, Lipkin WI  "Discovery and implication of a novel arenavirus in a cluster of fatal transplant associated disease" New England Journal of Medicine 358 991 2007

    ? Hornig M, Briese T, Buie T, Bauman M, Lauwers G, Siemetzki U, Hummel, K, Rota P, Bellini W, O?Leary J, Sheils O, Alden E, Pickering L, Lipkin WI "Absence of measles virus and clinical profiles in enteropathy associated with autism" PLoS One 3(9) e3140 2008

    ? Briese T, Paweska JT, McMullan LK, Hutchison SK, Street C, Palacios G, Khristova ML, Weyer J, Swanepoel R, Egholm E, Nichol ST, Lipkin WI  "Genetic detection and characterization of LuJo virus, a new hemorrhagic fever-associated arenavirus from southern Africa" PLoS Pathogens 5(5) e1000455 2009

    Lipkin WI "Microbe Hunting" Microbiology and Molecular Biology Reviews 74 363 2010

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Contact Information

Office/Address:

Center for Infection and Immunity, 722 West 168th Street, Room 1703a

New York, NY 10032

USA

Website Address:

Homepage URL

Phone:

212-342-9033

Fax:

212-342-9044

E-mail:

wil2001@columbia.edu