Dr. Perzanowski's research is focused on understanding exposures that lead to allergic sensitization and asthma. While many environmental exposures are hypothesized to have contributed to the global asthma epidemic that started in the latter half of the 20th century, a unifying theory has not been proven. Dr. Perzanowski began his research career at a preeminent allergen exposure laboratory and participated in studies conducted in communities as different as inner-city Atlanta and rural Kenya. He continued with his doctoral research working with the OLIN group in northern Sweden at the Arctic Circle where asthma is common but dust mites and cockroaches, exposure to which is important to asthma elsewhere, are not found. As a co-investigator on several established prospective cohort studies, Dr. Perzanowski?s current research is exploring paradigms of exposures related to asthma in an area of the world with one of the greatest asthma burdens, low and middle-income neighborhoods in New York City. He is the principal investigator on the NIH (NIEHS) and HUD funded, NYC Neighborhood Asthma and Allergy Study which is examining neighborhood differences in asthma prevalence and persistence to better understand the disparity in asthma risk between children living just city blocks apart. Two other major research aims of his laboratory work are implementing non-invasive measurements of airway inflammation in pediatric population based studies and evaluating the relevance of the 'hygiene hypothesis' to inner-city asthma.
Honorable Mention, Phadia Allergy Research Forum Award , 2009
Selected New York City Activities:
NYC Neighborhood Asthma and Allergy Study
Within New York City, the reported prevalence of pediatric asthma and hospitalization rates for asthma vary markedly between adjacent neighborhoods. The NYC Neighborhood Asthma and Allergy Study is examining neighborhood differences in asthma prevalence and asthma persistence to better understand the great difference in asthma risk among children living just city blocks apart. We hypothesize that the differences are due to greater exposure to asthma/allergy environmental triggers, including indoor cockroach and mouse allergens and local sources of combustion byproducts. The study is enrolling seven year-old children who reside in NYC and are enrolled in the HIP Health Plan and following them to age ten. This study is novel in that it is examining populations with striking difference in asthma prevalence despite being geographically close (and thus exposed to many of the same things), of a similar income, and with similar access to health care.
Selected Global Activities:
Obstructive Lung Diseases in Northern Sweden
Dr. Perzanowski is a senior researcher involved with a longitudinal cohort study of pediatric asthma and allergy.
World Health Organization (WHO) Urban Pests and Health Project
Dr. Perzanowski was a scientific contributor to the WHO Urban Pests and Health Project, co-authoring a chapter on asthma and allergy in the urban environment.
Cornell AG, Chillrud SN, Mellins RB, Acosta LM, Miller RL, Quinn JW, Yan B, Divjan A, Olmedo OE, Lopez-Pintado S, Kinney PL, Perera FP, Jacobson JS, Goldstein IF, Rundle AG, Perzanowski MS "Black carbon and dust mite exposures are associated independently with exhaled NO in children in NYC" J Exposure Sci Enir Epi 22 258-66 2012
Price JB, Divjan A, Montfort WR, Freyer GA, Perzanowski MS "IgE against bed bug (Cimex lectularius) allergens are common among adults bitten by bed bugs" J Allergy Clin Immunol 129 863-5 2012
Olmedo OE, Acosta LM, Goldstein IF, Divjan A, Rundle AG, Chew GL, Mellins RB, Hoepner L, Andrews H, Lopez-Pintado S, Quinn JW, Perera FP, Miller RL, Jacobson JS, Perzanowski MS "Cockroach, mouse and dust mite allergen exposure and sensitization among children living in high and low asthma prevalence neighborhoods in New York City" J Allergy Clin Immunol 128 284-92 2011
Rosa MJ, Divjan A, Hoepner L, Sheares BJ, Diaz D, Gauvey-Kern K, Perera FP, Miller RL, Perzanowski MS "Fractional exhaled nitric oxide exchange parameters among nine year-old inner-city children" Ped Pulmonolgy 46 83-91 2011
Perzanowski MS, Miller RL, Tang D, Ali DB, Garfinkel RS, Chew GL, Goldstein IF, Perera FP, Barr RG "Prenatal acetaminophen exposure and risk of wheeze at age 5 years in an urban, low-income cohort." Thorax 65 118-23 2010
Perzanowski MS, Chew GL, Divjan A, Johnson A, Panjwani K, Sheares BJ, Goldstein IF, Garfinkel RS, Platts-Mills TA, Perera FP, Miller RL "Cat ownership is a risk factor for developing anti-cat IgE but not wheeze at age 5 in a low income urban NYC cohort" J Allergy Clin Immunol in press 2008
Perzanowski MS, Chew CG, Aalberse R, de Blay F "Allergic Asthma" Public Health Significance of Urban Pests Ed. Bonnefoy, Kampen, Sweeney World Health Organization Copenhagen/Denmark 7-52 2008
Perzanowski MS, Miller RL, Thorne PS, Barr RG, Divjan A, Sheares BJ, Garfinkel RS, Goldstein IF, Perera FP, Chew GL "Endotoxin inner-city homes and the association with atopy and wheeze in the first two years of life." J Allergy Clin Immunology in press 2006
Perzanowski MS, Ronmark E, Platts-Mills TA, Lundback B "The protective effect of having a cat or dog at home on developing asthma in pre-teen age children." Amer J Respir Crit Care Med 166 696-702 2002
Perzanowski MS, Ng?ang?a LW, Carter MC, Odhiambo J, Ngari W,Vaughan JW, Chapman MD, Kennedy MW, Platts-Mills TA "Atopy, asthma and antibodies to Ascaris among rural and urban children in Kenya: markers of allergy do not predict bronchial hyper-reactivity in a rural community." J Pediatr 140 582-588 2002