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Joseph H. Graziano

Professor of Environmental Health Sciences

Professor of Pharmacology, College of Physicians and Surgeons

Dr. Joseph Graziano's research career has been devoted to understanding the consequences of exposure to metals, both on the molecular and population levels. Human exposure to metals occurs via a number of different scenarios that include exposure in the workplace; in the home, such as lead paint, or arsenic in drinking water, or outdoors; due to airborne emissions from industry or transportation vehicles. In the past, Dr. Graziano's research was almost entirely devoted to lead poisoning, which has contributed to understanding the adverse effects of lead exposure on childhood development. As a pharmacologist, his laboratory developed the oral drug that is now used to treat children with lead poisoning. More recently, Dr. Graziano's work has taken him to Bangladesh, where his current research is aimed at understanding the consequences of arsenic exposure on the Bangladeshi population, and on devising strategies to reduce toxicity and provide arsenic-free drinking water, a problem that spans beyond the political borders of Bangladesh, to much of South Asia, from India to Vietnam. Recent findings that both arsenic and manganese, both elevated in Bangladesh drinking water, are associated with cognitive deficits in children, add urgency to solving this enormous public health and environmental problem.
Education & Training:

    PhD, 1971, Rutgers University

    BS, 1967, Long Island University


University Affiliations:

  • Earth Institute at Columbia University  Member, Academic Committee

Additional Affiliations:

  • Member, Society for Pediatric Research
  • Member, Society of Toxicology
  • Member, American Society of Hematology
  • Member, American Society of Public Health
  • Member, Society for Occupational and Environmental Health
  • Member, New York Academy of Sciences
Honors and Awards:
  • Andrew Mellon Teacher Scientist Award, Cornell Medical College, 1978
  • Award and Medallion from the Medical Faculty of the University of Kosovo, Pristina, Yugoslavia, 1986
  • Award for Special Achievements in the Field of Health, Kosovska Mitrovica, Yugoslavia, 1986
  • Teacher of the Year, Mailman School of Public Health, 2002
  • The Dean?s Excellence in Leadership Award, 2009
New York City
    Columbia NIEHS Center for Environmental Health in Northern Manhattan
    Joseph Graziano is the founding director of this Center, and served as its director for eight years. In that capacity, and as Chair of the Department of Environmental Health Sciences at the time, he initiated a research program - either personally or through recruitment of faculty - that addresses the environmental health concerns of our communities. In addition, through interactions with the West Harlem Environmental Action (WE ACT), he has cultivated a number of community-based research projects.

    Health Effects and Geochemistry of Arsenic Project URL: http://superfund.ciesin.columbia.edu/home.html

    Dr. Graziano is the Director of Columbia University's Superfund Basic Research Program, entitled "Health Effects and Geochemistry of Arsenic and Lead." This research program includes a set of seven research projects, three of which take place in Bangladesh, where naturally occurring arsenic in drinking water has led to the exposure of nearly 40 million people. Approximately 15 Columbia faculty, from the Mailman School, the College of Physicians and Surgeons, and the Lamont-Doherty Earth Observatory are involved. The three research projects in Bangladesh are: 1) a cohort study of arsenicosis in Bangladesh; 2) environmental arsenic, pregnancy and children's health; and 3) arsenic mobilization in Bangladesh groundwater.
    Countries: Bangladesh

    Environmental Lead, Reproduction, and Infant Development
    From 1983 to 1998, Dr. Graziano directed a long-term prospective study of environmental lead exposure in Kosovo. The town of Kosovska Mitrovica is a heavily lead-exposed area, due to the presence of a large mining, smelting, and battery production industry. Pristina, the capital city of Kosovo, is relatively unexposed. This 15-year prospective study is considered to be one of the landmark studies that associated childhood lead exposure with impaired cognitive function in children.
    Countries: Serbia and Montenegro

Selected Publications:
  • Wasserman, G., Liu, X., Parvez, F., Ahsan, H., Factor-Litvak, P., Kline, J., van Geen, A., Slavkovich, V., LoIacono, N., Levy, D., Cheng, Z., Graziano, J.H. Water arsenic exposure and intellectual function in six year-old children in Araihazar, Bangladesh. Environ Health Perspect 115 285-289. 2007
  • Graziano J, Slavkovich V, Liu X, Factor-Litvak P, Todd AC A prospective study of prenatal and childhood lead exposure and erythropoietin production Occupational and Environmental Medicine 46 924-929 2004
  • Wasserman, G.A., Liu, X., Parvez, F., Ahsan, H., Levy, D., Factor-Litvak, P., Kline, J., van Geen, A., Slavkovich, V., LoIacono, N.J., Cheng, Z., Zheng, Y., Graziano, J.H. Water manganese exposure and children's intellectual function in Araihazar, Bangladesh Environmental Health Perspectives 114 124-129. 2006
  • Opler MG, Brown AS, Graziano J, Desai M, Zheng W, Schaefer C, Factor-Litvak P, Susser ES Prenatal lead exposure, delta-aminolevulinic acid, and schizophrenia Environmental Health Perspectives 112 548-52 2004
  • Ahsan, H., Chen, Y., Kibriya, M.G., Slavkovich, V., Parvez, F., Jasmine, F., Gamble, M., Graziano, J.H. Arsenic metabolism, genetic susceptibility and risk of pre-malignant skin lesions in Bangladesh. Cancer Epidemiol Biomarker Prev 16 1270-1278 2007
  • Van Geen A, Cheng Z, Seddique AA, Hoque MA, Gelman A, Graziano JH, Ahsan H, Parvez F, Ahmed KM Reliability of the Hach kit to test groundwater for arsenic in Bangladesh Environmental Science and Technology In press 2004
  • Li, Y., Chen, Y., Slavkovic, V., Ahsan, H., Parvez, F., Graziano, J.H., Brandt-Rauf, P. Serum levels of the extracellular domain of the epidermal growth factor receptor in individuals exposed to arsenic in drinking water in Bangladesh. Biomarkers 12 256-265 2007
  • Wasserman G, Liu X, Parvez F, Ahsan H, Factor-Litvak P, Van Geen A, Slavkovich V, LoIacono N, Cheng Z, Hussain I, Momotaj H, Graziano JH Water arsenic exposure and children's intellectual function in Araihazar, Bangladesh Environmental Health Perspectives 112 1329-1333 2004
  • Argos, M., Parvez, M.F., Hussain, A.Z.M.I., Momotaj, H., Dhar, R., van Geen, A., Howe, G.R., Graziano, J.G., Ahsan, H. Influence of socioeconomic factors on the effects of arsenic on premalignant skin lesions - results from the Health Effects of Arsenic Longitudinal Study (HEALS). Amer J Pub Health 97 825-831 2007
  • Wasserman G, Factor-Litvak P, Liu X, Todd AC, Kline J, Slavkovich V, Popovac D, Graziano JH The relationship between blood lead, bone lead and child intelligence Child Neuropsychology 9 22-34 2003

Contact Information


722 W. 168th St, Rosenfield Bldg -1107

New York 10032