Dr. Andrew Rundle's research focuses on physical activity and body weight with a primary interest in whether sedentary lifestyles and overweight/obesity are risk factors for cancer development. This work includes investigations of the determinants of physical activity and body weight, creating new methods to measure physical activity, molecular epidemiologic investigations of mechanisms through which physical activity may prevent cancer, and studies of associations between activity and cancer incidence. Dr. Rundle also is involved in a project investigating whether environmental exposures cause prostate cancer. In addition to his teaching responsibilities at the Mailman School, which include the Environmental Epidemiology and Molecular Epidemiology courses, he lectures at the School of Social Work and teaches epidemiology to journalism students at NYU. Dr. Rundle also is involved with IARC's international training workshops on Molecular Epidemiology.
Dr. Rundle is leading a series of studies to determine whether characteristics of neighborhood's social and built environments (e.g. access to public transport, parks, crime, zoning, trees, community gardens, traffic volume) influence health. Much of the research focuses on obesity related outcomes in adults and children, however the team is also conducting research on childhood asthma and developmental outcomes. The project is also developing novel methods to measure characteristics of neighborhoods.
Selected Global Activities:
Physical Activity and Lung Cancer in GEN-AIR/EPIC
An investigation of whether increased physical activity prevents lung cancer in ex- and non-smokers. The project is designed as case-control study nested in the EPIC cohort, and is using biomarkers to test hypotheses regarding the mechanisms through which physical activity exerts effects.
Countries: United Kingdom
Rundle A, Tang D, Hibshoosh H, Estabrook A, Schnabel F, Cao WF, Grumet S, Perera F The relationship between genetic damage from polycyclic aromatic hydrocarbons in breast tissue and breast sancer. Carcinogenesis 21 1281-1289 2000
Rundle A, Tang D, Hibshoosh H, Schnabel F, Kelly A, Levine R, Zhou J, Link B, Perera F Molecular epidemiologic studies of polycyclic aromatic hydrocarbon-DNA adducts and breast cancer. Environmental and Molecular Mutagenesis 39 201-7 2002
Ahsan H, Rundle A Measures of genotype vs. gene products: promise and pitfalls in cancer prevention Carcinogenesis 24 1229-34 2003
Rundle A, Schwartz S Issues in the epidemiologic analysis and interpretation of intermediate biomarkers Cancer Epidemiology Biomarkers and Prevention 12 491-496 2003
Rundle A, Tang D, Mooney L, Grumet S, Perera F The interaction between alcohol consumption and GSTM1 genotype on PAH-DNA adduct levels in breast tissue Cancer Epidemiology Biomarkers and Prevention 12 911-4 2003
Rundle A Molecular epidemiology of physical activity and cancer Cancer Epidemiology Biomarkers and Prevention 14 227-236 2005
Rundle AG, Vineis P, Ahsan H. Design options for molecular epidemiology research within cohort studies. Cancer Epidemiol Biomarkers Prev. 14 1899-907 2005
Gatto N, Campbell U, Rundle A, Ahsan H Further development of the case-only design for assessing gene-environment interaction: evaluation of and adjustment for bias International Journal of Epidemiology in press 2004
Rundle A, Roux AV, Free LM, Miller D, Neckerman KM, Weiss CC. The urban built environment and obesity in New York City: a multilevel analysis. American Journal of Health Promotion 21 326-34 2007
Rundle A, Field S, Park Y, Freeman L, Weiss CC, Neckerman K. Personal and neighborhood socioeconomic status and indices of neighborhood walk-ability predict body mass index in New York City. Social Science and Medicine 67 1951-8 2008