The Exposome Boot Camp: Measuring Exposures on an Omic Scale

Most recent Exposome Boot Camp in NYC: July 25-26, 2019. Join our email list below to hear about the next training!

 

The Exposome Boot Camp is a two-day intensive boot camp of seminars and hands-on analytical sessions to provide an overview of concepts, techniques, and data analysis methods used in studies of the exposome.       

 

 

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Boot Camp OVERVIEW

Summer 2019 dates: July 25-26, 2019; 9:00am - 5:00pm

There are many challenges to capturing the complexity of exposures in an individual across the lifetime and their potential health effects. Traditionally, environmental health studies have focused on assessing risks related to a single exposure at a time, yet in reality we are constantly exposed to multiple exposures at the same time. To advance environmental health research and positively impact human health through recommendations and policy, we need to incorporate omics data that capture all chemical species detectable in human plasma over the life course. The exposome offers this framework and can be viewed as the environmental complement of the genome.

This two-day intensive boot camp integrates the principle concepts of exposomics and the untargeted approaches of measuring endogenous and exogenous chemical exposures on an omic scale as we step through the tools and techniques currently available to analyze the exposome. Led by a team of expert scientists in the rapidly growing field of exposomics, the boot camp will integrate seminar lectures with hands-on computer lab sessions to put concepts into practice. Emphasis will be given to leveraging existing resources from ongoing studies and initiating new investigations. The afternoon lab sessions will provide an opportunity to work hands-on with real data. Participants will learn and practice data handling, cleaning, and basic analysis of exposomics data.

By the end of the workshop, participants will be familiar with the following topics:

  • Principles of exposomics
  • Concept ideation and study design
  • Laboratory methods and instrumentation platforms for analysis
  • Data extraction and cleaning with emphasis on peaks and feature tables
  • Pathway data analysis and identification databases
  • Data visualization and network interpretation
  • Study design advantages and pitfalls
  • Emerging exposomic topics and laboratory platforms

Investigators at all career stages are welcome to attend, and we particularly encourage trainees and early-stage investigators to participate.

PREREQUISITES AND REQUIREMENTS

This training is designed to accommodate investigators with varying experience levels in R. Both beginner and advanced data manipulation during lab sessions will be available, with all material and additional resources available after the training.  

  1. Each participant must have an introductory background in statistics

  2. Each participant is required to bring a personal laptop with R downloaded and installed prior to the first day of the workshop as all lab sessions will be done on your personal laptop. R is available for free download and installation on Mac, PC, and Linux devices.  

  3. The Boot Camp will use data sets in R, therefore we strongly recommend that participants have a basic understanding of this platform prior to attending the Boot Camp. It is ok if you have never used this platform before because the tutorials outlined below will provide you with the basic skills needed for Boot Camp success.

R TUTORIALS

Knowing basic R platform and commands are highly recommended for the Boot Camp as noted in prerequisites above. If you are new to R or need a refresher, you can review the below tutorials to be well prepared:

If you have any specific questions about R and R studio in the context of The Exposome Boot Camp, please email us.

SCHOLARSHIPS

Training scholarships are available for the Exposome Boot Camp.

LOCATION

The Exposome Boot Camp will take place on the Columbia University Irving Medical Center (CUIMC) Campus in New York City, specifically at Columbia Mailman School of Public Health, 722 W. 168th Street, Allan Rosenfield Building 8th Floor Auditorium. Please note that the entrance to the building is on the 10th floor (training is located two floors below entrance).

General transportation and lodging information can be found in the Getting Around sectionA PDF map of the 2019 Boot Camp location on the CUIMC campus will be available closer to training dates. 

KEYNOTE SPEAKER

Emma Schymanski, PhD, University of Luxembourg. Dr. Schymanski is head of the Environmental Cheminformatics group at the Luxembourg Centre for Systems Biomedicine, University of Luxembourg and received a Luxembourg National Research Fund (FNR) ATTRACT Fellowship in 2018. Her research combines cheminformatics and computational non-target mass spectrometry approaches to elucidate the unknowns in complex samples and relate these to environmental causes of disease. An advocate for open science, she is involved in and organizes several European and worldwide activities to improve the exchange of data, information and ideas between scientists to push progress in this field.

INSTRUCTORS

Training Director: Gary Miller, PhD, Professor of Environmental Health Sciences and Vice Dean of Research Strategy and Innovation, Mailman School of Public Health, Columbia University. Dr. Miller was the founding Director of the HERCULES Center at Emory University, the first exposome-based research center in the U.S. and authored the first book on the topic, The Exposome: A Primer published by Elsevier. His laboratory at Columbia focuses on environmental drivers of neurodegeneration, using several experimental models from cultured neurons and C. elegans to mice and human studies.

Dean Jones, PhD, Professor of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, Emory University. Dr. Jones is the Director of the Emory Clinical Biomarkers Laboratory, where he leads a collaborative team in developing high-resolution metabolomics for personalized medicine and also serves as Co-Leader of the Integrated Health Sciences Facility Core at the HERCULES Exposome Research Center.

Megan Niedzwiecki, PhD, Assistant Professor, Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mt. Sinai.

Karan Uppal, PhD, Assistant Professor, Medicine, Emory University. Dr. Uppal is the Director of Computational Metabolomics in the Clinical Biomarkers Laboratory at Emory, where he develops different R packages and web applications for processing, annotating, analyzing and integrating metabolomics, transcriptomics, and epigenomics data.

Doug Walker, PhD, Assistant Professor, Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mt. Sinai. Dr. Walker formerly served as the Director of Exposome Research for the Clinical Biomarkers Laboratory and was a member of the HERCULES Exposome Research Center at Emory University. His current research focuses on the continued development and application of advanced analytical strategies for measuring the occurrence, distribution and magnitude of previously unidentified environmental exposures and assist in delineating the mechanisms underlying environment-related diseases in humans.

 

REGISTRATION FEES

 Early-Bird Rate (through 5/15/19)Regular Rate (5/16/19 - 7/11/19)Columbia Discount*
Student/Postdoc/Trainee     $1,150 $1,35010%
Faculty/Academic Staff/Non-Profit Organizations  $1,350 $1,55010%
Corporate/For-Profit Organizations$1,550$1,750NA

*Columbia Discount: This discount is valid for any active student, postdoc, staff, or faculty at Columbia University. To access Columbia discount, email Columbia.Exposome@gmail.com for instructions.

Registration Fee: includes course material, breakfast, lunch, and refreshment breaks. Course material will be available to all students after the workshop. Lodging and transportation are not included.  

Cancellations: Cancellation notices must be received via email at least 30 days prior to the workshop start date in order to receive a full refund, minus a $50 administrative fee. Cancellation notices received via email 14-29 days prior to the workshop will receive a 50% refund, minus a $50 administrative fee. Please email your cancellation notice to Columbia.Exposome@gmail.com. Due to workshop capacity, we regret that we are unable to refund registration fees for cancellations after these dates. 

If you are unable to attend the training, we encourage you to send a substitute within the same registration category. Please inform us of the substitute via email at least one week prior to the training to include them on attendee communications, updated registration forms, and materials. Should the substitute fall within a different registration category your credit card will be credited/charged respectively. Please email substitute inquiries to Columbia.Exposome@gmail.com.

ADDITIONAL INFORMATION

 

 

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Questions? Email the Boot Camp team here.

The Exposome Boot Camp is hosted by Columbia University's Department of Environmental Health Sciences in the Mailman School of Public Health and the Irving Institute for Clinical and Translational Research, with additional support from the Society of Toxicology (SOT).