Assistant Professor in Epidemiology
EDUCATION & TRAINING
University of Wales, Bangor, United Kingdon, B.Sc. Zoology, 2001
University of Oxford/Institute for Animal Health, Pirbright, United Kingdom, D.Phil, Molecular Virology, 2007
Emerging infectious diseases
Dr. Anthony's research seeks to understand the underlying causes of disease emergence and spread. It concentrates on the discovery and characterisation of viral pathogens in both wildlife and people and aims to understand the factors that drive viral diversity, evolution, and host switching. He is currently the co-lead for discovery and characterisation for the USAID PREDICT project, a $100 million effort to characterise the zoonotic pool (diversity of viruses in wildlife) and understand the pathways of spillover and spread in people. He has adopted a highly integrative approach to public health research by applying theory and method from related disciplines such as epidemiology and ecology to the study of viral diversity, and by focusing on the interface between wildlife and human health (the ‘One Health’ concept). Dr. Anthony's research foci include:
1. Predicting Disease Emergence: Despite greater recognition of the threats that zoonotic viruses pose, we have never successfully predicted the emergence of a new infectious disease in people. One of Dr. Anthony's specific questions is whether viral diversity in wildlife is inherently predictable? Being able to predict how viruses in the zoonotic pool might respond to environmental change (for example climate, or land-use) would allow us to test response options designed to mitigate, or adapt to, the impact of those changes and reduce the risk of zoonotic emergence.
2. Drivers of Disease Emergence: Understanding the factors that increase disease emergence risk is an important aspect of the PREDICT project. Such factors may include host species traits or environmental drivers such as land-use change or climate. The ‘Deep Forest’ project is a component of PREDICT that specifically addresses land-use change, an ecological driver that is believed to account for nearly half of all zoonotic disease events. Currently being implemented in the Amazon (Brazil), the Impenetrable Forest (Uganda) and in Sabah (Malaysian Borneo), this project is evaluating how increasing land-use development affects 1) patterns of host biodiversity (bats, rodents and primates), 2) corresponding patterns of viral diversity and 3) patterns of human occupancy, abundance and behavior that may influence contact rates with wildlife.
3. Characterization of Emerging Pathogens: Dr. Anthony seeks to characterize viruses that emerge in new hosts (both humans and wildlife) as pathogens. Demonstrating causation (where possible) and looking for genetic clues that might identify and explain host-switching or increased virulence are key to a predictive understanding of which viruses might pose a zoonotic threat.
Key countries of engagement: Bangladesh, Brazil, Malaysia, Uganda, Mexico, Bolivia
Anthony, S.J; St. Leger, J.A; Liang, E; Hicks, A.L; Sanchez-Leon, M.D; Jain, K; Lefkowitch, J; Navarrete-Macias, I; Knowles, N; Solovyov, A; Goldstein, T; Pugliares, K; Ip, H.S; Rowles, T; Lipkin, W.I. Discovery of a novel hepatovirus (Phopivirus of seals) related to human hepatitis A virus. MBio. 2015 Aug 25;6(4). pii: e01180-15.
Anthony, S.J; Islam, A; Johnson, C; Navarrete-Macias, I; Liang, E; Jain, K; Hitchens, P.L; Che, X; Soloyvov, A; Hicks, A.L; Ojeda-Flores, R; Ulrich, W; Rostal, M.K, Epstein, J.H; Petrosov, A; Garcia, J; Haider, N; Wolfe, N; Goldstein, T; Morse, S.S; Rahman, M; Mazet, J; Daszak, P; Lipkin, W.I. Non-random patterns in viral diversity. Nat Commun. 2015 Sep 22;6:8147.
Bogich, T.L; Anthony, S.J; Nichols, J.D. Surveillance theory applied to virus detection: A case for targeted discovery (Special Report). Future Virol. 2014; 8(12):1201-1206.
Anthony, S.J; Garner, M.M; Palminteri, L; Navarrete-Macias, I; Sanchez-Leon, M.D; Briese, T; Daszak, P; Lipkin, W.I. West Nile virus in the British Virgin Islands. Ecohealth. 2014 Jun;11(2):255-7.
Anthony, S.J; Epstein, J.H; Murray, K.A; Navarrete-Macias, I; Zambrana-Torrelio, C.M; Solovyov, A; Ojeda-Flores, R; Arrigo, N.C; Islam, A; Ali Khan, S; Hosseini, P; Bogich, T.L; Olival, K.J; Sanchez-Leon, M.D; Karesh, W; Goldstein, T; Luby, S.P; Morse, S.S; Mazet, JAK; Daszak, P; Lipkin, W.I. A strategy to estimate unknown viral diversity mammals. MBio. 2013 Sep 3;4(5):e00598-13.
Anthony, S.J; St. Leger, J.A; Navarrete-Macias, I; Nilson, E; Sanchez-Leon, M; Liang, E; Seimon, T; Jain, K; Daszak, P; Briese, T; Lipkin, W.I. Polyomavirus in a common dolphin (Delphinus delphis) with tracheobronchitis. PLoS One. 2013 Jul 10;8(7):e68239.
Goldstein, T; Mena, I; Anthony, S.J; Medina; R; Robinson, P.W; Greig, D.J; Costa, D.P; Lipkin, W.I; Garcia-Sastre, A;Boyce, W .M. Pandemic H1N1 Influenza Isolated from Free-Ranging Northern Elephant Seals in 2010 off the Central California Coast. PLoS One. 2013 May 15;8(5):e62259.
Anthony, S.J; Ojeda-Flores, R; Rico-Chavez, O; Navarrete-Macias, I; Zambrana-Torrelio, C; Rostal, M.K; Epstein, J.H; Tipps, T; Liang, E; Sanchez-Leon, M.D; Sotomayor-Bonilla, J; Aguirre, A.A; Avila-Flores, R; Medellin, R.A; Goldstein, T; Suzan, G; Daszak, P; Lipkin, W.I. Coronaviruses in bats from Mexico. J Gen Virol. 2013 May;94(Pt 5):1028-38.
Anthony, S.J; St Leger, J.A; Pugliares, K; Ip, H.S; Chan, J.M; Carpenter, Z.W; Navarette-Macias, I; Sanchez-Leon, M; Saliki, J.T; Pedersen, J; Karesh, W; Daszak, P; Rabadan, R; Rowles, T; Lipkin, W.I. Emergence of fatal influenza in New England Harbor seals. MBio. 2012 Jul 31;3(4):e00166-12.
LaMere, S.A; St.Leger, J.A; Schrenzel, M.D; Anthony, S.J; Rideout, B.A; Salomon, D.R. Molecular characterization of a novel gammaretrovirus in killer whales (Orcinus orca). J Virol. 2009 Dec;83(24):12956-67.