Nischay Mishra, PhD

Associate Research Scientist
Phone: 212.342.5176
Fax: 212.342.9044
Email: nm2641@columbia.edu



 

 

EDUCATION & TRAINING

Lucknow University, Lucknow, India, BSc (Biology), 2001
Kanpur University, Kanpur, India, MSc (Biotechnology), 2004
National Institute of Virology (University of Pune), India, PhD, Biotechnology, 2011

RESEARCH INTERESTS

Rapid and broad-spectrum molecular and serological techniques for identifying unknown infectious agents
Genomic and evolutionary phylogenetic analysis of emerging DNA and RNA viruses
Genome mutation and changes in virulence and transmissibility of viral agents
Association of disease and disease progression with changes in the microbiome

BIO

Dr. Mishra is a virologist and molecular biologist with over 10 years of experience in high throughput sequencing, viral metagenomics, serology, viral epidemiology, diagnostics and bioinformatics. His achievements include the identification of a novel polyomavirus associated with disease in a transplant recipient exposed to Superstorm Sandy floodwaters, assistance in the discovery of Middle East Respiratory virus in bats and camels in the Kingdom of Saudi Arabia, and contributions to the development of the VirCapSeq-VERT, a diagnostic platform that screens for all known vertebrate viruses present in a sample and also detects novel viruses with up to 60% genome divergence from known sequence. 

PUBLICATIONS​

  • Briese T, Kapoor A, Mishra N, Jain K, Kumar A, Jabado OJ, Lipkin WI. Virome Capture Sequencing Enables Sensitive Viral Diagnosis and Comprehensive Virome Analysis. MBio. 2015 Sept-Oct; 6(5). doi: 10.1128/mBio.01491-15
  • Ly N, Tokarz R, Mishra N, Sameroff S, Jain K, Rachmat A, An U, Newell S, Harrison DJ, Lipkin WI. Multiplex PCR analysis of clusters of unexplained viral respiratory tract infection in Cambodia. Virol J. 2014 Dec 17; 11(1): 224.
  • Mishra N, Pereira M, Rhodes RH, An P, Pipas JM, Jain K, Kapoor A, Briese T, Faust PL, Lipkin WI. Identification of a novel polyomavirus in a pancreatic transplant recipient with retinal blindness and vasculitic myopathy. J Infect Dis. 2014 Nov 15;210(10):1595-9.
  • Briese T*, Mishra N*, Jain K, Zalmout IS, Jabado OJ, Karesh WB, Daszak P, Mohammed OB, Alagaili AN, Lipkin WI. Middle East respiratory syndrome coronavirus quasispecies that include homologues of human isolates revealed through whole-genome analysis and virus cultured from dromedary camels in Saudi Arabia.  MBio. 2014 Apr 29;5(3):e01146-14.
  • Alagaili AN, Briese T, Mishra N, Kapoor V, Sameroff SC, Burbelo PD, de Wit E, Munster VJ, Hensley LE, Zalmout IS, Kapoor A, Epstein JH, Karesh WB, Daszak P, Mohammed OB, Lipkin WI. Middle East respiratory syndrome coronavirus infection in dromedary camels in Saudi Arabia. MBio. 2014 Feb 25; 5(2):e00884-14.
  • Memish ZA, Mishra N, Olival KJ, Fagbo SF, Kapoor V, Epstein JH, Alhakeem R, Durosinloun A, Al Asmari M, Islam A, Kapoor A, Briese T, Daszak P, Al Rabeeah AA, Lipkin WI. Middle East respiratory syndrome coronavirus in bats, Saudi Arabia. Emerg Infect Dis. 2013 Nov; 19(11): 1819-23.
  • Mishra N, Walimbe AM, Arankalle VA. Hepatitis E virus from India exhibits significant amino acid mutations in fulminant hepatic failure patients. Virus Genes. 2013 Feb; 46(1): 47-53. doi: 10.1007/s11262-012-0833-7. 
  • Burbelo PD, Dubovi EJ, Simmonds P, Medina JL, Henriquez JA, Mishra N, Wagner J, Tokarz R, Cullen JM, Iadarola MJ, Rice CM, Lipkin WI, Kapoor A. Serology-enabled discovery of genetically diverse hepaciviruses in a new host. J Virol. 2012 Jun;86(11):6171-8. 
  • Mishra N, Arankalle VA. Association of polymorphisms in the promoter regions of TNF-α (-308) with susceptibility to hepatitis E virus and TNF-α (-1031) and IFN-γ (+874) genes with clinical outcome of hepatitis E infection in India. J Hepatol. 2011 Dec; 55(6): 1227-34.