Angela Rasmussen, PhD

Associate Research Scientist
Phone: 212.305.8178
Fax: 212.342.9044
Email: alr2105@columbia.edu



 

 

EDUCATION & TRAINING

Smith College, Northampton, MA, BA (Biological Sciences), 2000
Columbia University, New York, NY, MA (Microbiology), 2005
Columbia University, New York, NY, MPhil (Microbiology), 2006
Columbia University, New York, NY, PhD (Microbiology), 2009
University of Washington, Seattle, WA, post-doctoral fellow (Microbiology), 2009-2012

RESEARCH INTERESTS

Systems biology analysis of the relationship between host response to infection and disease outcome
Experimental model development for highly pathogenic viruses
Virus-host interactions and mechanisms of pathogenesis
Sex-specific differences in susceptibility to viral disease
Translational applications of host response signatures

BIO

Dr. Rasmussen is a virologist studying host responses to infection by combining classical virology with modern systems biology approaches. Her research objectives are to identify host response signatures predictive of infection severity or disease outcome and host pathways to target drug development or repurposing. She is particularly interested in viruses that are highly pathogenic, newly emergent or likely to emerge because of climate change, land development, or ecological disruption.

Dr. Rasmussen has employed Collaborative Cross (CC) mouse models, which provide an expanded range of disease presentations, to study viral disease characteristics. At the University of Washington, she developed a CC mouse model of Ebola virus disease, utilizing the diversity of CC mouse disease phenotypes to study genetic and transcriptomic factors underlying disease severity in humans. She is currently evaluating CC mouse models towards investigation of sex-specific host responses to viral infection, as well as to investigate disease presentation in other viruses that pose a major threat to global public health, such as dengue and influenza viruses. Ultimately, these host response profiles can be used for translational or biodefense applications, such as diagnosing infection, predicting disease severity, informing vaccine design, and developing or repurposing host-targeted drugs to impair virus replication or reverse pathology.

PUBLICATIONS​

  • Rasmussen AL. Host Factors in Ebola Infection. Ann Rev Genomics Hum Genet. 2016 May 4; Epub ahead of print. PMID: 27147086.
  • Rasmussen AL, Tchitchek N, Safronetz D, Carter VS, Williams CM, Haddock E, Korth MJ, Feldmann H, Katze MG.  Delayed inflammatory and cell death responses are associated with reduced pathogenicity in Lujo virus-infected cynomolgus macaques.  J Virol 2015 Mar 1;89(5):2543-52. PMID: 25520505. PMCID: PMC4325716.
  • Rasmussen AL, Okumura A, Ferris MT, Green R, Feldmann F, Kelly SM, Scott DP, Safronetz D, Haddock E, LaCasse R, Thomas MJ, Sova P, Carter VS, Weiss JM, Miller DR, Shaw GD, Korth MJ, Heise MT, Baric RS, de Villena FP, Feldmann H, Katze MG. Host genetic diversity enables Ebola hemorrhagic fever pathogenesis and resistance. Science. 2014; 346(6212):987-91. PMID: 25520505. PMCID: PMC4241145
  • Falzarano D, de Wit E, Feldmann F, Rasmussen AL, Okumura A, Peng X, Thomas MJ, van Doremalen N, Haddock E, Nagy L, LaCasse R, Liu T, Zhu J, McLellan JS, Scott DP, Katze MG, Feldmann H, Munster VJ. Infection with MERS-CoV Causes Lethal Pneumonia in the Common Marmoset. PLoS Pathog. 2014 Aug 21;10(8):e1004250. doi:10.1371/journal.ppat.1004250. eCollection 2014 Aug. PMID: 25144235. PMCID: PMC4140844.
  • de Wit E, Rasmussen AL, Feldmann F, Bushmaker T, Martellaro C, Haddock E, Okumura A, Proll SC, Chang J, Gardner D, Katze MG, Munster VJ, Feldmann H. Influenza Virus A/Anhui/1/2013 (H7N9) Replicates Efficiently in the Upper and Lower Respiratory Tracts of Cynomolgus Macaques. MBio. 2014 Aug 12;5(4). pii: e01331-14. doi: 10.1128/mBio.01331-14. PMID: 25118237. PMCID: PMC414568
  • Falzarano D, de Wit E, Rasmussen AL, Feldmann F, Okumura A, Scott DP, Brining D, Bushmaker T, Martellaro C, Baseler L, Benecke AG, Katze MG, Munster VJ, Feldmann H. Treatment with interferon-α2b and ribavirin improves outcome in MERS-CoV-infected rhesus macaques. Nat Med. 2013 Oct;19(10):1313-7. doi: 10.1038/nm.3362. Epub 2013 Sep 8. PMID: 24013700. PMCID: PMC
  • de Wit E, Rasmussen AL, Falzarano D, Bushmaker T, Feldmann F, Brining DL, Fischer ER, Martellaro C, Okumura A, Chang J, Scott D, Benecke AG, Katze MG, Feldmann H, Munster VJ. Middle East respiratory syndrome coronavirus (MERS-CoV) causes transient lower respiratory tract infection in rhesus macaques. Proc Natl Acad Sci U S A. 2013 Oct 8;110(41):16598-603. doi: 10.1073/pnas.1310744110. Epub 2013 Sep 23. PMID: 24062443. PMCID: PMC3799368.
  • Rasmussen AL, Wang IM, Shuhart MC, Proll SC, He Y, Cristescu R, Roberts C, Carter VS, Williams CM, Diamond DL, Bryan JT, Ulrich R, Korth MJ, Thomassen LV, Katze MG. Chronic immune activation is a distinguishing feature of liver and PBMC gene signatures from HCV/HIV coinfected patients and may contribute to hepatic fibrogenesis. Virology. 2012 Aug 15;430(1):43-52. PMID: 22608059. PMCID: PMC3371131.
  • Rasmussen AL, Tchitchek N, Susnow NJ, Krasnoselsky AL, Diamond DL, Yeh MM, Proll SC, Korth MJ, Walters KA, Lederer S, Larson AM, Carithers Jr. RL, Benecke A, and Katze MG.  Early Transcriptional Programming Links Progression to Hepatitis C Virus-Induced Severe Liver Disease in Transplant Patients.  Hepatology 2012 Jul;56(1):17-27. PMID: 22278598. PMCID: PMC3349763.
  • Rasmussen AL, Diamond DL, McDermott JE, Gao X, Metz TO, Matzke MM, Carter VS, Belisle SE, Korth MJ, Waters KM, Smith RD, Katze MG. Systems virology identifies a mitochondrial fatty acid oxidation enzyme, dodecenoyl coenzyme A delta isomerase, required for hepatitis C virus replication and likely pathogenesis. J Virol. 2011 Nov;85(22):11646-54. PMID: 21917952. PMCID: PMC3209311.