The Effect of Childhood Immune Imprinting on 1918 and Other Flu Pandemics

11:00 am
12:00 pm
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Michael Worobey, D. Phil.
University of Arizona
Lecture Series
Department of Environmental Health Sciences
Center for Infection and Immunity
Open to the Columbia Community
I will discuss evidence that influenza A virus antigens to which humans are initially exposed as kids dramatically shape the severity of future infections. Profound protection is apparent even against "novel" hemagglutinin subtypes, but apparently only if they are matched to the phylogenetic group of the initial infection. This provides a framework for predicting both the age distribution of future cases and the potential of successful emergence into humans of new flu strains from animal reservoirs.


Ellen Kobak