L.H. Lumey

L.H. Lumey

L.H. Lumey

Professor
Epidemiology at the Columbia University Medical Center

Office/Address:

722 West 168 Street, Rm 1617
New York NY USA 10032
Phone:
212-305-9222
Fax:
212-342-5169
Email:

Biography

Dr. Lumey studied medicine at the Universities of Leiden and Amsterdam in the Netherlands and history and philosophy of science at Darwin College, University of Cambridge, England. He was awarded a Fulbright fellowship to study at Columbia University where he obtained MPH and PhD degrees in epidemiology. After returning to the Netherlands, Dr Lumey worked at the Academic Medical Center of the University of Amsterdam and the National Institute for Public Health and Environmental Protection RIVM. He later joined the American Health Foundation in New York and was Director of the New York City Perinatal HIV Transmission Collaborative Study before being recruited to the Department of Epidemiology at Columbia. Over the last decades, Dr Lumey completed a number of single and multi-generation cohort studies worldwide to investigate the relation between maternal nutrition in pregnancy and health outcomes in the offspring. These studies include men and women exposed to malnutrition during the Ukraine famine of 1932-33, the Dutch famine of 1944-45, and the Chinese famine of 1959-61. He has reported extensively on morbidity and mortality, including birth outcomes, infant growth, and adult health, including epigenetic changes. With collaborators in Leiden, he published in 2008 the first study in humans linking prenatal famine to persisting epigenetic changes in DNA methylation of the IGF2 gene. Further studies in the Dutch famine population show that DNA methylation could be an epigenetic mediator of the impact of prenatal nutrition on adult health.

Education

PhD, 1988, Columbia University
MPH, 1985, Columbia University
MD, 1982, Univ of Amsterdam, Netherlands
Other, 1977, Darwin College, Cambridge University, UK

Editorial Boards

International Journal of Epidemiology

Other Affiliations

Molecular Epidemiology Department, Leiden University Medical Center, Netherlands

Honors & Awards

Fulbright Fellow, Columbia University, 1982-1986
Lorentz Fellow, Royal Netherlands Academy of Arts and Sciences, NIAS, Wassenaar, 2008-09
George G. Graham Annual Lecture, Center for Human Nutrition, Johns Hopkins University, 2015

Select Global Activities

Visiting Professor, Department of Biosciences and Nutrition, Karolinska Institutet, Stockholm, 2013, Sweden
Visiting Professor, Universidade Federal de Ciencias da Saude de Porto Alegre, Brazil, 2014, Brazil

Select Publications

L.H.Lumey, A.C.Ravelli, L.G.Wiessing, J.G.Koppe,P.E.Treffers, Z.A.Stein. The Dutch famine birth cohort study: design, validation of exposure, and selected characteristics of subjects after 43 years follow-up. Paediatr Perinat Epidemiol 7:354-67, 1993 L.H.Lumey, A,D.Stein, H.S.Kahn, K. van der Pal-de Bruin, G.J.Blauw, P.A.Zybert, E.S.Susser. Cohort profile: the Dutch Hunger winter families study. Int J Epidemiol 36: 1196-207, 2007 A.D.Stein, H.S.Kahn, A. Rundle, P.A.Zybert, K. van der Pal-de Bruin, L.H.Lumey. Anthropometric measures in middle age after exposure to famine during gestation: evidence from the Dutch famine. Am J Clin Nutr 85: 869-76, 2007 B.T.Heijmans, E.W.Tobi, A.D.Stein, H.Putter, G.J.Blauw, E.S.Susser, P.E.Slagboom, L.H.Lumey. Persistent epigenetic differences associated with prenatal exposure to famine in humans. Proc Natl Acad Sci U S A 105: 17046-9, 2008 E.W.Tobi, J.J.Goeman, R.Monajemi, H.Gu, H.Putter, Y.Zhang, R.C.Slieker, A.P.Stok, P.E.Thijssen, F.Müller, E.W.van Zwet, C.Bock, A.Meissner, L.H.Lumey, P.E.Slagboom, B.T.Heijmans BT. DNA methylation signatures link prenatal famine exposure to growth and metabolism. Nature Comm Nov 26, 2014. doi:10.1038/ncomms6592 P.Ekamper, F.van Poppel, A.D.Stein, G.E.Bijwaard, L.H.Lumey. Prenatal Famine Exposure and Adult Mortality through Age 63 Years from Cancer, Cardiovascular Disease and Other Causes. Am J Epidemiol 181: 271-279, 2015 E.W. Tobi, R.Slieker, A.D.Stein, H.E.D.Suchiman, P.E.Slagboom, E.W.van Zwet, B.T.Heijmans, L.H.Lumey. Early gestation as the critical time-window for changes in the prenatal environment to affect the adult human blood methylome. Int J Epidemiol (in press)

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