Jing Shen

Jing Shen

Jing Shen

Adjunct Associate Research Scientist
Environmental Health Sciences at the Columbia University Medical Center

Office/Address:

630 W 168th St, Room 19-418
New York NY USA 10032
Phone:
212-305-8158
Fax:
212-305-5328
Email:

Biography

Dr. Jing Shen's research interest is in the field of molecular epidemiology of cancers with focus on understanding the role of genetic alternations and their interactions with environmental factors in populations. His previous work includes studies of DNA repair genotype, phenotype and their associations with breast cancer risk; studies to determine the role of telomere dysfunction in breast cancer risk, and the potential modifying effects of oxidative damage, antioxidant capacity and genetic polymorphisms in key telomere stability genes. His current researches will continue focus on the role of telomere dysfunction, genetic and epigenetic changes on the risk of breast, liver, gastric and prostate cancers.

Topics

Education

PhD, 2001, Peking University
MS, 1990, Nanjing Medical University
MD, 1985, Nanjing Medical University

Areas of Expertise

Risk Assessment and Communication, Genetic Susceptibility, Genetics

Select Publications

Jin G., Wang L., Chen W., Hu Z., Zhou Y., Tan Y., Wang J., Hua Z., Ding W., Shen J., Zhang Z., Xu Y., Shen H. Variant alleles of TGFB1 and TGFBR2 are associated with a decreased risk of gastric cancer in a Chinese population. Int. J. Cancer 120 1330-5 2006
Wang L., Chen W., Wang J., Tan Y., Zhou Y., Ding W., Hua Z., Shen J., Xu Y., Shen H. Reduced folate carrier gene G80A polymorphism is associated with an increased risk of gastroesophageal cancers in a chinese population. Eur. J. Cancer 42 3206-11 2006
Santella R.M. Gammon M.D., Terry M.B., Senie R., Shen J., Kennedy D., Agrawal M., Zhang F.F. DNA adducts, DNA Repair Genotype/Phenotype and Cancer Risk. Mutat. Res. 592 29-35 2005
Shen J., Terry M.B., Gurvich I., Liao Y., Senie R.T., Santella R.M. Short telomere length and breast cancer risk: a study in sister-sets. Cancer Res. 67 5538-44 2007
Jin G., Miao R., Deng Y., Hu Z., Zhou Y., Tan Y., Wang J., Hua Z., Ding W., Wang L., Chen W., Shen J., Wang X., Xu Y., Shen H. Variant genotypes and haplotypes of the epidermal growth factor gene promoter are associated with a decreased risk of gastric cancer in a high-risk Chinese population. Cancer Sci. 98 864-868 2007
Zhang Y.J., Wu H.C., Shen J., Ahsan H., Tsai W., Yang H., Wang L., Chen S., ChenC., Santella R.M. Predicting Hepatocellular Carcinoma by Detection of Aberrant Promoter Methylation in Serum DNA. Clin. Cancer Res. 13 2378-84 2007
Shen J., Terry M.B., Gammon M.D., Gaudet M.M., Zhang F.F., Teitelbaum S.L., Eng S.M., Sagiv S.K., Neugut A.I., Santella R.M. MGMT genotype modulates the associations between cigarette smoking, dietary antioxidants and breast cancer risk. Carcinogenesis 26 2131-7 2005
Shen J., Gammon M.D., Terry M.B., Teitelbaum S.L., Neugut A.I., Santella R.M. Genetic polymorphisms in the cyclo-oxygenase-2 gene, use of nonsteroidal anti-inflammatory drugs, and breast cancer risk. Breast Cancer Res. 20 R71 2006
Shen J., Wang R.T., Xu Y.C., Wang L.W., Wang X.R. Interaction Models of CYP1A1, GSTM1 Polymorphisms and Tobacco Smoking in Intestinal Gastric Cancer. World J. Gastroenterology 11 6056-60 2005
Wang L., Ke Q., Chen W., Wang J., Tan Y., Zhou Y., Hua Z., Ding W., Niu J., Shen J., Zhang Z., Wang X., Xu Y., Shen H. Polymorphisms of MTHFD, plasma homocysteine levels, and risk of gastric cancer in a high-risk Chinese population. Clin. Cancer Res. 13 2526-32 2007
Shen J., Desai M., Agrawal M., Kennedy D.O., Senie R.T., Santella R.M., Terry M,B. Polymorphisms in nucleotide excision repair genes and DNA repair capacity phenotype in sisters discordant for breast cancer. Cancer Epidemiol Biomarkers & Prev. 15 1614-9 2006
Shen J., Terry M.B., Gammon M.D., Gaudet M.M., Teitelbaum S.L., Eng S.M., Sagiv S.K., Neugut A.I., Santella R.M. IGHMBP2 Thr671Ala polymorphism might be a modifier for the effects of cigarette smoking and PAH-DNA adducts to breast cancer risk. Breast Cancer Res Treat., 99 1-7 2006
Shen J., Gammon M.D., Terry M.B., Zhang F.F., Wang L.W., Wang Q., Teitelbaum S.L., Eng S.M., Sagiv S.K., Gaudet M.M., Neugut A.I., Santella R.M. Polymorphisms in XRCC1 modify the association between PAH-DNA adducts, cigarette smoking, dietary antioxidants and breast cancer risk. Cancer Epidemiol Biomarkers & Prev. 14 336-42 2005
Kennedy D.O., Agrawal G., Shen J., Terry M.B., Zhang F., Senie R.T., Motykiewicz G., Santella R.M. DNA repair capacity of lymphoblastoid cell lines from sisters discordant for breast cancer. J. Natl. Cancer Inst., 97 127-32 2005
Shen J., Wang R.T., Wang L.W., Xu Y.C., Wang X.R. A novel genetic polymorphism of inducible nitric oxide synthase (iNOS) is associated with higher risk of gastric cancer in a Chinese population. World J. Gastroenterology 10 3278-83 2004

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