Dr. Denise Kandel's major research interests are in the epidemiology, risk factors and consequences of drug use; the epidemiology of substance dependence; comorbidity between substance use and psychiatric disorders; developmental pathways of problem behaviors in adolescence; and the intergenerational transmission of deviance. Her current work focuses almost exclusively on the epidemiology and etiology of smoking and nicotine dependence in adolescence. Dr. Kandel currently is conducting a major longitudinal study of the transition from experimental smoking to nicotine dependence in adolescence and early adulthood, in which she is following a cohort of over 1,000 adolescents and their mothers. She had pioneered charting the developmental phases of drug use and identified the specific risk factors for adolescent initiation into each major stage, which provided the basis for the Gateway Hypothesis. Dr. Kandel has initiated a novel area of research, focused on the molecular bases of epidemiological paradigms, in particular the Gateway Hypothesis, in mice in collaboration with Drs. Eric Kandel and Amir Levine from the Center for Neurobiology and Behavior.
Honors & Awards
Areas of Expertise
Select Global Activities
Nicotine dependence among adolescents, Sweden: Comparative study of the epidemiology and risk factors for nicotine dependence among high school students in the United States and Sweden.
Kandel DB, Wu P,Davies M Maternal smoking during pregnancy and smoking by adolescent daughters American Journal of Public Health 84 1407-1413 1994
Hu, M.C., Muthen, B., Schaffran, C., Griesler, P., Kandel, D. Developmental Trajectories of Criteria of Nicotine Dependence in Adolescence Drug and Alcohol Dependence 98 94-104 2008
Jon Clark (ed.) James S. Coleman: Falmer Sociology Series Falmer Press London 33-45 1996
Kandel DB The parental and peer contexts of adolescent deviance: an algebra of interpersonal influences Empirical Validity of Theories of Durg Abuse (Journal of Drug Issues, Special Issue, H. White, ed.) 26 289-315 1996
Kandel DB, Johnson JG, Bird HR, Weissman MM, Goodman SH, Lahey BB, Regier DA, Schwab-Stone ME Psychiatric comorbidity among adolescents with substance use disorders: findings from the MECA Study Journal of the American Academy of Child and Adolescent Psychiatry 38 693-699 1999
Kandel DB (ed.) Stages and Pathways of Drug Involvement: Examining the Gateway Hypothesis Cambridge University Press Cambridge, England 2002
Kandel DB Does marijuana use cause the use of other drugs? JAMA 289 482-483 2003
Kandel DB, Kiros GE, Schaffran C, Hu MC Racial/ethnic differences in cigarette smoking initiation and progression to daily smoking: a multilevel analysis American Journal of Public Health 94 128-135 2004
Hu MC, Davies M, Kandel DB Epidemiology and correlates of daily smoking and nicotine dependence amoung young adults in the U.S. American Journal of Public Health (in press) 2005
Denise B. Kandel, Mei-Chen Hu, Christine Schaffran, J. Richard Udry and Neal Benowitz Urine nicotine metabolites, smoking and nicotine dependence in a multiracial/ethnic national sample of young adults American Journal of Epidemiology 165 901-910 2007
Denise B. Kandel, Mei-Chen Hu, Pamela C. Griesler and Christine Schaffran On the development of nicotine dependence in adolescence Drug and Alcohol Depdendence In print 2007