Brandon Pearson behavioral neuroscientist and toxicologist. Dr. Pearson's research focuses on the biology of brain disease and aging. In particular, his group studies the impact of complex environmental stressors on neurotoxicological outcomes, germ line epigenetic inheritance, and aging. The lab utilizes a combination of cellular and animal models, molecular biology, and bioinformatics. Through a combination of expertise in neurotoxicology, epigenetics, stress, and behavioral models, the lab has a unique strength in evaluating of human-relevant environmental stressors with the potential to contribute to complex disease. The lab is currently focusing research on how complex stressors and chemicals alone, or in association with each other, alter developmental processes implicated in neurodevelopment, neurodegeneration, aging, and cancer in order to define effective precision prevention strategies.
Areas of Expertise
Healthy Aging and Longevity, Autism, Neurodevelopmental Disorders, Environmental Toxins, Toxicology, Epigenetics, Gene-Environment Interactions, Genetics
Xie K, Ryan DP, Pearson BL, Henzel KS, Neff F, Vidal RO, Hennion M, Lehmann I, Schleif M, Schroeder S, Adler T, Rathkolb B, Rozman J, Schueltz A, Prehn C, Edvar M, Weiergraeber M, Adamski J, Busch DH, Ehninger G, Matynia A, Jackson WS, Wolf E, Fuchs H, Gailus-Durner V, Bonn S, Hrabe de Angelis M, Ehninger D. (2018). Epigenetic alterations in longevity regulators, reduced lifespan and exacerbated aging-related pathology in old father offspring mice. Proceedings of the National Academy of Sciences U.S.A 115(10):E2348-E2357.
Xie K, Neff F, Markert A, Rozman J, Aguilar-Pimentel JA, Amarie OV, Becker L, Brommage R, Garrett L, Henzel KS, Hoelter SM, Janik D, Lehmann I, Moreth K, Pearson BL, Racz I, Rathkolb B, Ryan DP, Schroeder S, Treise I, Bekeredjian R, Busch DH, Graw J, Ehninger G, Klingenspor M, Klopstock T, Ollert M, Sandholzer M, Schmidt-Weber C, Weiergraeber M, Wolf E, Wurst W, Zimmer A, Gailus-Durner V, Fuchs H, Hrabe de Angelis M, Ehninger D (2017). Every-other-day feeding extends lifespan but fails to delay many symptoms of aging in mice. Nature Communications 8, 155.
Ryan DP, Henzel KS, Pearson BL, Siwek ME, Papazoglou A, Paesler K, Mueller R, Xie K, Schroeder S, Becker L, Garrett L, Hoelter SM, Neff F, Racz I, Rathkolb B, Rozman J, Ehninger G, Klingenspor M, Klopstock T, Wolf E, Wurst W, Zimmer A, Fuch H, Guilus-Durner V, Hrabe de Angelis M, Sidiropoulou K, M Weiergraeber M, Ehninger D (epub, Ahead of Print, Accepted for publication, 14 Feb 2017). A paternal methyl donor-rich diet altered cognitive and neural functions in offspring mice. Molecular Psychiatry
Pearson BL, Ehninger D (2017). Environmental chemicals and aging. Current Environmental Health Reports 4:38-43.
Pearson BL, Simon JM, McCoy ES, Salazar G, Fragola G, Zylka MJ (2016). Identification of chemicals that mimic transcriptional changes associated with autism, brain aging and neurodegeneration. Nature Communications 7:11173.
King IF, Yandava CN, Mabb AM, Hsiao JS, Huang H, Pearson BL, Calabrese JM, Starmer J, Parker JS, Magnuson T, Chamberlain SJ, Philpot BD, Zylka MJ. (2013). Topoisomerases facilitate transcription of long genes linked to autism. Nature 501: 58-62.
Pearson BL, Corley MJ, Vasconcellos A, Blanchard DC, Blanchard RJ (2013). Heparan sulfate deficiency in autistic postmortem brain tissue from the subventricular zone of the lateral ventricles. Behavioural Brain Research 243: 138-145
Sugawara A, Pearson BL, Blanchard DC, Ward MA. 2012. Mouse females devoid of exposure to males during fetal development exhibit increased maternal behavior. Psychoneuroendocrinology 37(3): 383-395.
Maeng S, Hunsberger J, Pearson B, Yuan P, Wei Y, McCammon J, Schloesser RJ, Zhou R, Du J, Chen G, McEwen B, Reed JC, & Manji HK. 2008. BAG1 plays a critical role in regulating recovery from both manic-like and depression-like behavioral impairments. Proceedings of the National Academy of Sciences U.S.A. 105(25), 8766-8771.