Dr. Brown's main area of research is on the identification of early antecedents for schizophrenia, bipolar disorder, and autism. Among his major findings, he was the first to demonstrate that serologically documented prenatal exposure to influenza, rubella, toxoplasmosis, and inflammatory biomarkers are potential risk factors for schizophrenia. He leads 2 NIH-funded research grants aimed at identifying risk factors for schizophrenia and autism in a large national Finnish birth cohort, in collaboration with Turku University and THL in Finland. He also leads a large birth cohort study on the antecedents of bipolar disorder in northern California. Additionally, Dr. Brown leads a Conte Center Project on prenatal SSRIs and neuropsychiatric outcomes in Finland. He is on the core faculty of several research fellowships and has mentored over 30 trainees. He is the recipient of several awards in clinical psychiatric research, including the A.E. Bennett Research Award. He has received numerous research grants as PI from the NIMH, NIEHS, NARSAD, and other funding agencies. He is a fellow of the American College of Neuropsychopharmacology and the WPA Section on Epidemiology. Dr. Brown is an author or co-author of over 140 peer-reviewed publications, reviews, and book chapters.
BS, 1983, Johns Hopkins University
MD, 1987, Jefferson Medical College
MPH, 2007, Columbia University Mailman School of Public Health
Honors & Awards
Areas of Expertise
Longitudinal Studies, Autism, Neurodevelopmental Disorders, Environmental Epidemiology, Environmental Risk Factors, Birth Outcomes, Depression, Schizophrenia
Parboosing R, Bao Y, Shen L, Schaefer CA, Brown AS. Gestational influenza and bipolar disorder in adult offspring. JAMA Psychiatry 2013; 70(7):677-685.
Brown AS, Sourander A, Hinkka-Yli-SalomÃƒÆ’Ã†â€™Ãƒâ€ Ã¢â‚¬â„¢ÃƒÆ’Ã¢â‚¬Â ÃƒÂ¢Ã¢â€šÂ¬Ã¢â€žÂ¢ÃƒÆ’Ã†â€™ÃƒÂ¢Ã¢â€šÂ¬Ã…Â¡ÃƒÆ’Ã¢â‚¬Å¡Ãƒâ€šÃ‚Â¤ki S, McKeague IW, Sundvall J, Surcel HM. Elevated maternal C-reactive protein and autism in a national birth cohort. Mol Psychiatry 2014; 19(2):259-264.
Brown AS, Surcel HM, Hinkka-Yli-SalomÃƒÆ’Ã†â€™Ãƒâ€ Ã¢â‚¬â„¢ÃƒÆ’Ã¢â‚¬Â ÃƒÂ¢Ã¢â€šÂ¬Ã¢â€žÂ¢ÃƒÆ’Ã†â€™ÃƒÂ¢Ã¢â€šÂ¬Ã…Â¡ÃƒÆ’Ã¢â‚¬Å¡Ãƒâ€šÃ‚Â¤ki S, Cheslack-Postava K, Bao Y, Sourander A. Maternal thyroid autoantibody and elevated risk of autism in a national birth cohort. Pro Neuropsychopharmacol Biol Psychiatry 2015; 57:86-92.
McKeague IW, Brown AS, Bao Y, Hinkka-Yli-SalomÃƒÆ’Ã†â€™Ãƒâ€ Ã¢â‚¬â„¢ÃƒÆ’Ã¢â‚¬Â ÃƒÂ¢Ã¢â€šÂ¬Ã¢â€žÂ¢ÃƒÆ’Ã†â€™ÃƒÂ¢Ã¢â€šÂ¬Ã…Â¡ÃƒÆ’Ã¢â‚¬Å¡Ãƒâ€šÃ‚Â¤ki S, Huttunen J, Sourander A. Autism with intellectual disability related to dynamics of head circumference growth during early infancy. Biol Psychiatry 2015; 77(9): 833-840.
Tran PL, Lehti V, Lampi KM, Helenius H, Suominen A, Gissler M, Brown AS, Sourander A. Smoking during pregnancy and risk of autism spectrum disorders in a Finnish National Birth Cohort. Paediatr Perinat Epidemiol 2013; 27(3):266-274.
Brown AS, Cohen P, Harkavy-Friedman J, Babulas V, Malaspina D, Gorman JM, Susser ES. A.E. Bennett Research Award. Prenatal rubella, premorbid abnormalities, and adult schizophrenia. Biol Psychiatry 2001; 49(6):473-486.
Brown AS, Begg MD, Gravenstein S, Schaefer CA, Wyatt RJ, Bresnahan M, Babulas VP, Susser ES. Serologic evidence of prenatal influenza in the etiology of schizophrenia. Arch Gen Psychiatry 2004; 61(8):774-780.
Brown AS, Hooton J, Schaefer CA, Zhang H, Petkova E, Babulas V, Perrin M, Gorman JM, Susser ES. Elevated maternal interleukin-8 levels and risk of schizophrenia in adult offspring. Am J Psychiatry 2004; 161(5):889-895.
Insel BJ, Schaefer CA, McKeague IW, Susser ES, Brown AS. Maternal iron deficiency and the risk of schizophrenia in offspring. Arch Gen Psychiatry 2008; 65(10): 1136-1144.
Talati A, Bao Y, Kaufman J, Shen L, Schaefer CA, Brown AS. Maternal smoking during pregnancy and bipolar disorder in offspring. Am J Psychiatry 2013; 170(10):1178-1185.