Diane Berengere Re

Diane Berengere Re

Diane Berengere Re

Unraveling the environmental triggers and the gene-environment interactions leading to adult-onset neurodegenerative diseases.
Assistant Professor
Environmental Health Sciences

Office/Address:


New York NY 10032
Phone:
212.305.6708
Email: CV:

Biography

From her early work, Dr. Diane Re has been interested in studying the cells called astrocytes, which normally support neuronal survival and transmission and whose importance in the brain is increasingly recognized. Dr. Re did her post-doctoral training at Columbia University under the mentorship of Prof. Serge Przedborski. There, she acquired extensive experience in neurodegeneration and in the adult-onset paralytic disorder Amyotrophic Lateral Sclerosis (ALS). Notably, her work pioneered the notion that in ALS motor neurons are degenerating due to the development of a hostile cellular environment. In particular, astrocytes undergo a transformation from benign supportive cells into potent motor neuron killers. Thereafter, she followed her interest in developing models of the sporadic form of ALS, which account for 90% of cases and may have a strong environmental component. On the basis of this effort in 2010, Dr. Re received a Career Development Award from the NIEHS Center of Northern Manhattan, which helped her to develop the first entirely humanized in vitro model of sporadic ALS by using cells directly produced from patients. More recently, using this in vitro model, Dr. Re and Dr. Guilarte have identified that translocator protein, TSPO, is a potential therapeutic target for motor neuron degeneration in ALS. Hypothesis that she is now testing thanks to a Department of Defense grant. Lately, Dr. Re obtained a Pilot Project Grant from the NIEHS Center of Northern Manhattan to examine another possible environmental trigger of motor neuron degeneration, the industrial metal manganese. Dr. Re is also developing some research work on the potential involvement of pesticides in ALS and dementia. Dr. Re's overarching goal is to unravel the potential environmental/occupational origins of neurodegenerative diseases and the importance of gene-environment interactions in their pathogenesis.

Topics

Education

BS, 1998, University of Aix-Marseille, France
MS, 2000, University of Aix-Marseille, France
PhD, 2004, University of Aix-Marseille, France

Mailman Affiliations

Faculty, Department of Environmental Health Sciences
Member, Columbia Center for Environmental Health in Northern Manhattan

Columbia Affiliations

Areas of Expertise

Neurological Disease / Disorders, Parkinson's Disease, Chemical Hazards, Environmental Risk Factors, Environmental Toxins, Toxicity of Heavy Metals, Toxicology
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