and: Co-leader Cancer Epidemiology Program and Director Biomarkers Shared Resource, Herbert Irving Comprehensive Cancer Center Director, Center for Environmental Health in Northern Manhattan
Dr. Regina Santella's research involves the use of biomarkers for the detection of human exposure to environmental and occupational carcinogens in molecular epidemiology studies to identify causative factors, susceptible populations, and preventive interventions. Her work has allowed the determination of exposure to carcinogens by the measurement of their binding to DNA with highly specific and sensitive immunoassays using monoclonal and polyclonal antibodies that her laboratory has developed. These studies have demonstrated higher levels of DNA damage in those with environmental or occupational exposures and in subjects with breast, lung, and liver cancer compared to controls. The role of genetic susceptibility in cancer risk is also being investigated. Current studies seek to understand the role of environmental/lifestyle factors on epigenetic changes and how they impact cancer risk as well as whether epigenetic changes in DNA methylation and microRNAs can be used for early diagnosis of cancer.
View Faculty CV here (PDF).
Biological Markers of Aflatoxin Exposure
Dr. Santella is working on a case-control study of hepatocellular cancer nested in a cancer screening cohort of 25,000 subjects. Biomarkers of exposure to environmental carcinogens, hepatitis virus infection, and epigenetic changes are being measured.
Shen J, Wang S, Zhang YJ, Kappil M, Wu HC, Kibriya MG, Wang Q, Jasmine F, Ahsan H, Lee PH, Yu MW, Chen CJ, Santella RM "Genome-wide DNA methylation profiles in hepatocellular carcinoma" Hepatology 55 1799-1808 2012
Lumey LH, Terry MB, Delgado-Cruzata L, Liao Y, Wang Q, Susser E, McKeague I, Santella RM. "Adult DNA methylation in relation to prenatal nutrition" Int J Epidemiol. 41 116-123 2012
Cho YH, Shen J, Gammon MD, Zhang YJ, Wang Q, Gonzalez K, Xu X, Bradshaw PT, Teitelbaum SL, Garbowski G, Hibshoosh H, Neugut AI, Chen J, Santella RM. "Prognostic significance of gene-specific promoter hypermethylation in breast cancer patients" Breast Cancer Res Treat. 131 197-205 2012
Terry MB, Delgado-Cruzata L, Vin-Raviv N, Wu HC, and Santella RM. "DNA methylation in white blood cells: Association with risk factors in epidemiologic studies" Epigenetics 6 828-837 2011
Hoque A., Ambrosone C.B., Till, C., Goodman, P.J., Tangen, C., Kristal, A., Lucia, S., Wang, Q., Kappil, M., Thompson, I., Hsing, A.W., Parnes, H., Lippman, S.M., Santella, R.M. "Serum oxidized protein and prostate cancer risk within the Prostate Cancer Prevention Trial" Hoque A., Ambrosone C.B., Till, C., Goodman, P.J., Tangen, C., Kristal, A., Lucia, S., Wang, Q., Kappil, M., Thompson, I., Hsing, A.W., Parnes, H., Lippman, S.M., Santella, R.M. Serum oxidized protein and prostate cancer risk within the Prostate Cancer Prevention Trial. Cancer Prevention Research 3, 478?483, 2010 3 478-483 2010
Zipprich, J., Terry, M.B., Liao, Y., Agrawal, M., Gurvich, I., Senie, R., and Santella, R.M. "Plasma protein carbonyls and breast cancer risk in sisters discordant for breast cancer from the New York site of the Breast Cancer Family Registry" Cancer Research 69 2966-2972 2009
Yazici, H., Terry, M.B., Cho, Y.H., Senie, R.T., Liao, Y., Andrulis, I., and Santella, R.M. "Aberrant methylation of RASSF1A in plasma DNA prior to breast cancer diagnosis in the Breast Cancer Family Registry" Epidemiology, Biomarkers & Prevention 19 2723-2725 2009
Zhang, Y-J., Wu, H-C., Shen, J., Ahsan, H., Tsai, W.Y., Yang, H.I., Wang, L.Y., Chen, S.Y., Chen, C.J. and Santella, R.M. "Predicting hepatocellular carcinoma by detection of aberrant promoter methylation in serum DNA." Clinical Cancer Research 13 2378-2384 2007
Kennedy, D.O., Agrawal, M., Shen, J., Terry, M.B., Zhang, F.F., Senie, R.T., Motykiewicz, G., and Santella, R.M. "DNA repair capacity of lymphoblastoid cell lines from sisters discordant for breast cancer" Journal of the National Cancer Institute 97 127-132 2005