Associate Professor at Columbia University Medical Center of Epidemiology
Mady Hornig, MD, MA, is Associate Professor of Epidemiology and Director of Translational Research in the Jerome L. and Dawn Greene Infectious Disease Laboratory at the Mailman School of Public Health, Columbia University. A physician-scientist, she is widely recognized for her animal model and clinical research on the role of microbial, immune, and toxicologic factors in neuropsychiatric disorders, including autism, schizophrenia, attention-deficit/hyperactivity disorder, obsessive-compulsive disorder, and mood disorders. Her work integrates data from animal models and epidemiologic studies to understand the mechanisms by which environmental factors, including viruses, bacteria, and toxins, or common host responses to these agents during brain maturation, may act as triggers or amplifying factors in the pathogenesis of some neuropsychiatric conditions. Findings from animal models of immune-mediated neurodevelopmental damage are employed to sharpen the focus of investigations in human cohorts, creating the basis for translation into novel biomarkers and intervention strategies; and hypotheses generated from epidemiologic studies are rigorously tested in animal models. In 2004, Dr. Hornig presented to the Institute of Medicine Immunization Safety Review Committee and testified twice before congressional subcommittees regarding the role of infections and toxins in autism pathogenesis. She leads a project on immune and neuroendocrine factors in West Nile virus encephalitis within the Northeast Biodefense Center, an NIAID regional center of excellence in biodefense and emerging infectious diseases, where she is a member of the Core Oversight Committee and the Governing Council. She was recently elected to the President's Council of Cornell Women.
American Medical Association (AMA) Rock Sleyster Memorial Scholar, 1987-1988
Association for Academic Psychiatry/Mead Johnson Fellow in Academic Psychiatry, 1992
NARSAD Young Investigator Award, 1993-1995
President?s Council of Cornell Women, 2004-2007
Selected Global Activities:
Gene-Environment Interactions in an Autism Birth Cohort
This project will describe the developmental trajectory of children with autism spectrum disorders, identify risk factors associated with the development of these disorders, and elucidate biologic markers (genetic, biochemical) present before or at birth that may help to predict children at risk for the development of these disorders.
Hornig M, Mozley PD, Amsterdam JD HMPAO SPECT brain imaging in treatment-resistant depression Prog Neuro-Psychopharmacol Biol Psychiatry 21 1097-114 1997
Hornig M, Goodman DBP, Kamoun M, Amsterdam JD Positive and negative acute phase proteins in affective subtypes J Affective Disord 49 9-18 1998