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Mady Hornig

Associate Professor of Epidemiology at the Columbia University Medical Center

Mady Hornig, MD, MA, is Associate Professor of Epidemiology and Director of Translational Research in the Jerome L. and Dawn Greene Infectious Disease Laboratory at the Mailman School of Public Health, Columbia University. A physician-scientist, she is widely recognized for her animal model and clinical research on the role of microbial, immune, and toxicologic factors in neuropsychiatric disorders, including autism, schizophrenia, attention-deficit/hyperactivity disorder, obsessive-compulsive disorder, and mood disorders. Her work integrates data from animal models and epidemiologic studies to understand the mechanisms by which environmental factors, including viruses, bacteria, and toxins, or common host responses to these agents during brain maturation, may act as triggers or amplifying factors in the pathogenesis of some neuropsychiatric conditions. Findings from animal models of immune-mediated neurodevelopmental damage are employed to sharpen the focus of investigations in human cohorts, creating the basis for translation into novel biomarkers and intervention strategies; and hypotheses generated from epidemiologic studies are rigorously tested in animal models. In 2004, Dr. Hornig presented to the Institute of Medicine Immunization Safety Review Committee and testified twice before congressional subcommittees regarding the role of infections and toxins in autism pathogenesis. She leads a project on immune and neuroendocrine factors in West Nile virus encephalitis within the Northeast Biodefense Center, an NIAID regional center of excellence in biodefense and emerging infectious diseases, where she is a member of the Core Oversight Committee and the Governing Council. She was recently elected to the President's Council of Cornell Women.
Education & Training:

    MD, 1988, Medical College of Pennsylvania

    MA, 1983, New School for Social Research

    BA, 1978, Cornell University


Mailman School Affiliations:

Additional Affiliations:

  • Member, American Psychiatric Association
  • Fellow, American Psychopathological Association
  • Member, International Society of NeuroVirology
  • Associate Member, American Society for Virology
Honors and Awards:
  • College Scholar, Cornell University, 1974-1978
  • American Medical Association (AMA) Rock Sleyster Memorial Scholar, 1987-1988
  • Association for Academic Psychiatry/Mead Johnson Fellow in Academic Psychiatry, 1992
  • NARSAD Young Investigator Award, 1993-1995
  • President?s Council of Cornell Women, 2004-2007
    Gene-Environment Interactions in an Autism Birth Cohort
    This project will describe the developmental trajectory of children with autism spectrum disorders, identify risk factors associated with the development of these disorders, and elucidate biologic markers (genetic, biochemical) present before or at birth that may help to predict children at risk for the development of these disorders.
    Countries: Norway

Selected Publications:
  • Hornig M, Mozley PD, Amsterdam JD HMPAO SPECT brain imaging in treatment-resistant depression Prog Neuro-Psychopharmacol Biol Psychiatry 21 1097-114 1997
  • Hornig M, Goodman DBP, Kamoun M, Amsterdam JD Positive and negative acute phase proteins in affective subtypes J Affective Disord 49 9-18 1998
  • Hornig M, Amsterdam JD, Kamoun M, Goodman DBP Autoantibody disturbances in affective disorders: a function of age and gender? J Affective Disord 55 29-37 1999
  • Hornig M, Weissenböck H, Horscroft N, Lipkin WI An infection-based model of neurodevelopmental damage Proc Natl Acad Sci USA 96 12102-7 1999
  • Weissenbock H, Hornig M, Hickey WF, Lipkin WI Microglial activation and neuronal apoptosis in Bornavirus infected neonatal Lewis rats Brain Pathol 10 260-72 2000
  • Hornig-Rohan M, Amsterdam JD Venlafaxine versus stimulant therapy in patients with dual diagnosis ADD and depression Prog Neuro-Psychopharmacol Biol Psychiatry 26 585-9 2002
  • Hoffman KL, Hornig M, Yaddanapudi K, Jabado O, Lipkin WI A murine model for neuropsychiatric disorders associated with group A beta-hemolytic streptococcal infection J Neurosci 24 1780-91 2004
  • Hornig M, Chian D, Lipkin WI Neurotoxic effects of postnatal thimerosal are mouse strain-dependent (advance online publication) Molec Psychiatry 8 June 2004 doi:10.1038/sj/mp.4001529 2004
  • Hornig M, Lipkin WI Infectious and immune factors in the pathogenesis of neurodevelopmental disorders: epidemiology, hypotheses, and animal models Mental Retardation Dev Disabil Res Rev 7 200-10 2001
  • Lipkin WI, Hornig M Neurovirology. Microbes and the brain. Lancet 352 SIV21 1999

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