Associate Professor of Clinical of Epidemiology (in the Sergievsky Center)
and: The Gertrude H. Sergievsky Center, College of Physicians and Surgeons
Joseph H. Lee, DrPH, studies the biology of aging traits in several unique populations in different parts of the world. To this end, he has three major areas of research. First, Dr. Lee and colleagues are studying large Caribbean Hispanic families with multiple affected relatives to identify genes for Alzheimer disease (AD). In addition to his work on late onset AD, he is focusing on early onset AD which is rare and has a strong genetic component. To identify novel AD genes, he applies genome-wide linkage and association, re-sequencing, gene expression, and functional genetic approaches. Dr. Lee has contributed to the identification and characterization of the SORL1 gene in late onset AD. Second, he and colleagues are examining the role of gene-environment interaction in common diseases, such as metabolic syndrome and osteoporosis. For this purpose, he is studying ethnic Koreans living in Kazakhstan and Korea, who share the same genetic background, but are exposed to disparate environments. He is extending this approach to two other ethnic groups in Kazakhstan and surrounding countries. Third, Dr. Lee is studying how genetic factors contribute to accelerated aging in humans by examining subjects with Down syndrome. In addition, he is involved in several family studies of common diseases, examining populations in the U.S., Dominican Republic, Puerto Rico, Kazakhstan, Korea, Venezuela and Honduras.
Member, International Society of Genetic Epidemiology
Member, Human Genome Organization
Member, American Association of Anthropological Genetics
Affiliate Member, American Academy of Neurology
Member, International Society of Psychiatric Genetics
Selected Global Activities:
Genetic epidemiology of aging traits in ethnic Koreans
The major aim of this study is to compare ethnic Koreans in Kazakhstan with those in China and Korea to understand genetic and environmental factors that influence normal variations in aging traits.
Countries: China; Kazakhstan; Korea, South
Genetic epidemiology of early onset Alzheimer disease (AD)
The goal of this study is to examine families that have multiple early onset AD to identify novel genetic variants, and also to identify genetic modifiers that alter age at onset of AD in individuals who carry an PSEN1 mutation.
Countries: Dominican Republic; Puerto Rico
Genetic epidemiology of telomere
The goal of this study is to understand the biology of aging by identifying risk factors that are associated with telomere length, which is a surrogate for cellular aging.
Countries: China; Kazakhstan; Korea, South; United States
Lee JH, Cheng R, Barral S, Reitz C, Medrano M, Lantigua R, Jim?nez-Velazquez IZ, Rogaeva E, St George-Hyslop P, Mayeux R "Genome wide association study in late-onset Alzheimer disease among Caribbean Hispanics supports CLU, PICALM, BIN1, and CUGBP2 and identifies novel loci" Archives of Neurology doi:10.1001/archneurol.2010.292 2010
Wijsman E, Pankratz N, Choi Y, Rothstein JH, Faber K, Cheng R, Lee JH, Bird T, Bennett DA, Diaz-Arrastia R, Goate A, Farlow M, Sweet RA, Foroud TM, Mayeux R for the NIA-LOAD/NCRAD Family Study Group. "Genome wide association of familial late onset Alzheimer?s disease replicates BIN1 and CLU and nominates CUGBP2 in interaction with APOE" PLoS Genetics In press
Lee JH, Cheng R, Rogaeva E, Meng Y, Stern Y, Santana V, Lantigua R, Medrano M, Jimenez-Velazquez IZ, Farrer LA, St. George-Hyslop P, Mayeux R "Further Examination of the Candidate Genes in Chromosome 12p13 Locus for Late-Onset Alzheimer Disease" Neurogenetics 9 127-138 2008
Lee JH, Cheng R, Honig L, Vonsattel J-P, Tycko B, Clark L, Mayeux R. "The Association between Genetic Variants in SORL1 and Autopsy-Confirmed Alzheimer?s Disease." Neurology doi:10.1212/01.wnl.0000280581.39755.89 2007
Rogaeva E*, Meng Y*, Lee JH*, Gu Y*, Kawarai T*, Zou F*, Katayama T, Baldwin CT, Cheng R, Hasegawa H, Chen F, ..., Der SD, Fraser PE, Schmitt-Ulms G, Younkin S, Mayeux R, Farrer LA, St George-Hyslop P "The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer?s Disease" Nature Genetics 39(2) 168-177 2007
Terwilliger JD, Lee JH "Natural Experiments in Human Gene Mapping: The intersection of Anthropological Genetics and Genetic Epidemiology" Anthropological genetics: Theory, methods and applications Ed. Crawford MH University of Cambridge Press Cambridge, UK 38-76 2006
Honig LS, Schupf N, Lee JH, Tang MX, Mayeux R. "Short telomere length is associated with mortality in those with APOE4 and those with dementia." Annals of Neurology 60 181-187 2006
Lee JH, Flaquer A, Stern Y, Tycko B, Mayeux R "Genetic influences on memory performance in familial Alzheimer?s disease" Neurology 62 414-421 2004
Lee JH "Genetic evidence for cognitive reserve: variations in memory and related cognitive functions" Journal of Clinical and Experimental Neuropsychology 25(5) 594-613 2003
Athan E, Williamson J, Ciappa A, Santana V, Romas SN, Lee JH, Zadroga HR, Lantigua R, Medrano M, Torres M-B, Arawaka S, Rogaeva E, Song Y, Sata C, Kawarai T, St. George-Hyslop P, Stern Y, Tycko B "A novel founder mutation Presenilin 1 causing familial, early onset Alzheimer?s disease in Caribbean Hispanics" JAMA 286(18) 2257-63 2001