Dr. Deliang Tang's primary research interest is in predictive risk modeling for cancer, particularly focusing on genetic susceptibility and environmental exposures. This interdisciplinary research consists of the development and validation of susceptibility and exposure/effect biomarkers and the development of statistical risk models. He is currently analyzing genotypes in ongoing studies of breast cancer, lung cancer, and chemoprevention, assessing whether these genotypes are associated with disease and how genotype interacts with environmental exposures. Dr. Tang's modeling work includes possible gene-environmental interactions, gene-gene interactions and gene-disease associations. A major goal of his research, which includes creating new predictive risk models and further developing the model to deal with the mass quantities of genetic data that are expected from the "gene chip" technology, is early cancer detection, based on biomarker analysis.
NYC Mothers and Newborns Study
In New York City, the CCCEH is conducting its largest prospective cohort study to evaluate prenatal and early postnatal risk factors in neurocognitive development, asthma etiology and cancer risk in African American and Latino mothers and newborns. Over 700 women are enrolled during pregnancy and their infants are followed through age five. A battery of data collection strategies are used, including multiple biomarkers, air monitoring and detailed questionnaires to determine exposure levels to a range of common urban air pollutants, pesticides, and indoor allergens. Specifically, researchers collect personal indoor and outdoor ambient air monitoring samples pre- and postnatally, and biologic samples are analyzed for markers of exposure and potential risk. Multiple questionnaires are administered to determine exposures to environmental tobacco smoke, particulate matter including diesel exhaust particulates (DEP), polycyclic aromatic hydrocarbons (PAH), nonpersistent pesticides, and home allergens (dust mite, mouse, cockroach). The effects of these exposures on children's health are estimated based on intermediate biomarkers and clinical data on neurodevelopment, asthma and other respiratory disorders.
The Effects of 9/11 on Pregnant Women and Newborns
The CCCEH World Trade Center 9/11 Study is assessing the effects of air pollutants released by the WTC destruction and during months of ensuing fires on the especially vulnerable popula